منابع مشابه
Anthrax toxin takes charge
Urge to merge erects filopodia rawling cells often produce both broad, flat lamellipodia and long, thin filopodia. Once formed, both structures appear to use an actin-treadmilling mechanism to extend themselves. During treadmilling, lamellipodia continuously nucleate new filaments, but filopodia continue to use the same filaments. So how does a cell form a filopodium in the first place? Svitkin...
متن کاملDefensins neutralize anthrax toxin
Anthrax causes an infectious disease mostly in pigs, cattle, horses, sheep and goats. The disease is rare in humans and occurs primarily in regions with intensive farming. The lethal toxin (LeTx) composed of the lethal factor (LF) and the protective antigen (PA) is mostly responsible for the high mortality of anthrax. Although Bacillus anthracis can be treated by antibiotics, this chemotherapy ...
متن کاملHow honey kills bacteria.
With the rise in prevalence of antibiotic-resistant bacteria, honey is increasingly valued for its antibacterial activity. To characterize all bactericidal factors in a medical-grade honey, we used a novel approach of successive neutralization of individual honey bactericidal factors. All bacteria tested, including Bacillus subtilis, methicillin-resistant Staphylococcus aureus, extended-spectru...
متن کاملAnthrax toxin rafts into cells
Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al. (2003) demonstrate that toxin oligomerization clusters the anthrax receptor into lipid rafts and this complex is internalized via the clathrin-dependent pathway.
متن کاملDesigning inhibitors of anthrax toxin.
INTRODUCTION Present-day rational drug design approaches are based on exploiting unique features of the target biomolecules, small- or macromolecule drug candidates and physical forces that govern their interactions. The 2013 Nobel Prize in chemistry awarded 'for the development of multiscale models for complex chemical systems' once again demonstrated the importance of the tailored drug discov...
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ژورنال
عنوان ژورنال: Science
سال: 2003
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.301.5641.1815a